Palmitoylethanolamide (PEA) is an endogenous fatty acid amide produced naturally in the body in response to harmful stimuli such as injury, pain & inflammation. Dietary sources of PEA include soybeans, egg yolk & peanuts. It is a component of the Endocannabinoid System (ECS) & exerts various biological effects via multiple routes of receptor activation. PEA has been validated by over 40 studies for various health benefits1, thus establishing it as a safe & scientifically supported substitute for Cannabidiol (CBD).

Regenate® is a patented, high-quality PEA, leveraging the full potential of PEA to the consumer with its versatility in various end-product applications.

The Regenate® difference

PEA’s hydrophobicity limits its application to tablets & capsules. Regenate® is an advanced formulation of PEA, meticulously crafted to offer a micronized & cold-water dispersible form through our innovative delivery technology.

This results in improved functionality for food & beverage applications, making it versatile in a wide range of delivery formats such as effervescent tablets, beadlets, gummies, RTD shots, beverages, stick packs & oral strips.

The Endocannabinoid system (ECS)

The ECS plays a crucial role in regulating various biological functions in the body. It consists of endocannabinoids & cannabinoid receptors that are widely distributed in the body. Endocannabinoids have been shown to contribute to the reestablishment of balance after insults; therefore, they may be beneficial for the modulation of pain, inflammation & metabolism2. 

Endocannabinoids include Anandamide or AEA (N-arachidonoylethanolamine) & 2-AG (2-arachidonoyl glycerol) that are produced at the nerve junctions & are thought to reduce nerve hyperactivity thereby inhibiting the transmission of pain. Additional members of this family include PEA. 

The endocannabinoid system is composed of three components:

N-arachidonoylethanolamine (AEA or Anandamide) & 2-arachidonoyl glycerol (2-AG).

Extended endocannabinoids:

Palmitoylethanolamide (PEA) & Oleoylethanolamine (OEA).

Unlike CBD, PEA is structurally related to the bliss molecule, Anandamide & may co-enhance its effects.

Cannabinoid receptors

CB1 (cannabinoid receptor-1) & CB2 (cannabinoid receptor-2)

Non-cannabinoid receptors

PPAR-α (Peroxisome proliferator-activated receptor) & TRPV1 (Transient receptor potential vanilloid-1)

MAGL (Monoacylglycerol lipase), NAPE (N-acyl-phosphatidylethanolamine), FAAH (Fatty acid amide hydrolase) & NAAA (N-acylethanolamine-hydrolysing acid amidase)

Mechanism of Action of PEA

PEA, a food component was first identified in 1957 & since then its anti-inflammatory, analgesic & neuroprotective effects have been well-established & documented through various studies in scientific literature. 

PEA is an endogenous lipid mediator produced on demand from the cell membranes. Its protective effects to counteract pain & inflammation are brought about by the activation of multiple receptors3,4.

Frequently Asked Questions

CBD is not produced by the human body unlike PEA, which is endogenously produced as a direct response & repair mechanism to inflammation. Moreover, CBD faces several challenges such as a lack of human clinical studies, legal complexities, safety concerns & regulatory restrictions whereas PEA has been substantiated by more than 40 studies for different health benefits1 , thereby making it a safe & scientifically supported substitute for Cannabidiol (CBD).

Regenate® is a patented, high-quality Palmitoylethanolamide (PEA), leveraging the full potential of PEA to the consumer with its versatility in various end-product applications. It has potential benefits to support joint health, muscle health & mobility leading to improved quality of life.

Regenate® can be formulated in various ready-to-use, end-product applications such as tablets, capsules, effervescent tablets, gummies, oral strips & beverages through our innovative technology platforms. Just let us know your dosage form & we will have a solution for you.

Regenate® is approved for use in several countries such as India, the United States, United Kingdom, Australia, Denmark, Italy & other European countries.

Collaborate with us

Our strength in formulation coupled with our manufacturing expertise will help you get to market faster.

Other Branded Ingredients

At Bio-gen Extracts, we believe in a future where health choices are well-informed and well-made. Join us on our mission to empower individuals worldwide to 'Choose Good Health™' through award-winning, scientifically-backed, and innovative nutraceutical ingredients.

icon icon icon icon

Products

Company

Blogs

Contact Us

+91 91089 93618
+91 91080 58822
sales@bio-gen.in
Privacy policyDisclaimers
© 2024 Bio-gen Extracts Pvt. Ltd. All Rights Reserved.